@pinkrose72 Sorry about the long post. I’m not trying to talk you into anything but I will tell you my experience. I want others to know too.
I too respond strangely to meds. So I am very careful. I am a retired RN. I don’t like taking meds unless I have to because I never know how I am going to respond. I have had bleeding ulcers, gastritis, esophagitis, still have a large hiatal hernia and I have NA cirrhosis, thyroid papillary cancer, Fibromyalgia. Been on esomeprazole for over 20 years for GERD, have not had increased acid reflux with these meds, I no longer eat the foods that exacerbate it. My Gastroenterologist said surgery, GLP or die. I chose GLP, as it was less invasive, though I was scared of side effects as I get nauseated with my liver so easily and it is miserable. I started on the starting dose of Tirzepatide, which is Zepbound or Mounjaro, has the lesser SE of the 2 meds. I was on it 2 months. I lost weight because I wasn’t eating correctly. Not nauseated just felt full all the time. Ate a couple bites and called it done. So was getting very little nourishment. I thought that’s how it was supposed to work. That’s totally wrong. You should be able to eat on the meds. After 2 months I was weak and miserable. Ate my 2 month check, my endocrinologist asked if I was ready to increase my dose, which sadly is the usual protocol. I said no I want to decrease it and told her my reasons. The smallest dose and still get the effect you want, Dr learn that in school. She hesitantly agreed. I cut my dose to 1.5mg and have taken that for 16 months never raising my dose. I have lost over 120# and just yesterday met my first goal intending to quit real soon another 5#. PCP aren’t equipped like obesity Drs they don’t fully know all about the drugs like obesity specialists, they can’t there are too many things to cover as a PCP. I am off all BP meds, my large dose of gabapentin for pain that I had been on 25+ years, I no longer have symptoms of GERD as I have changed my eating habits. I have decreased my thyroid meds 3x. Iam still on smallest dose of crestor, small dose esomeprazole, and my Synthroid. And generic stool softener. All side effects can be worked with and obesity specialists know how to work with it. Most nausea effects are self limited and go away with time. The only time I have been nauseated was when I ate something shouldn’t have(high fat-rib eye) or ate an amount(too much) I shouldn’t have. Mow that same steak is 3 meals. I had a MMJ gummy for nausea and it took care of it. I learned what not to eat and the amounts so I don’t get nausea. All the side effects can be treated…increased fluids, protein, fiber. A good dietician that knows how to work with GLPs. I am 69 years old. I wish they would have had this ages ago but I’m very thankful for them now. There is so much to know about these drugs and more coming to light, all the time. Obesity Specialists are real Drs with a specialty in Obesity Medicine, lists can be found on line and they have the most knowledge using these drugs. GPs and PCPs don’t have the experience treating the numbers of pts using GLPs these obesity Drs do. That’s my experience. Hopefully it can help someone.