@loribmt Good evening, I was 60 years old when I was diagnosed with IgG Lambda MGUS in February 2015. In May 2017, my M-spike started to rise to 3.0 g/dl., and a bone marrow biopsy showed 85% plasma cells. A fish panel confirmed t(14;16) in 18% of cells, and monosomy 13 in 21% of cells.
In July 2019, my IgG Lambda was .29 g/dl. A fish panel found monosomy 13 in 28% of cells, t(14;16) in 15% of cells and a gain of 1q and loss of 1p in 12% of cells.
In June 2020, a bone marrow biopsy showed 25% plasma cells and 0.3% myeloma cells. Another bone marrow biopsy in November 2020 showed 10-20% plasma cells by morphology and 1% myeloma cells. In December 2020, I had a second Autologous Stem Cell Transplant.
In January 2024, I received treatment with Talvey as bridging therapy. I underwent a CAR-T cell therapy in March 2024. It took me a few years to regain my normal everyday living.
In late September 2025, my Monoclonal IgG Lambda spiked to 0.4 mg/dL and there was an increase in my free light chains. In October 2025, I started Talvey.