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DiscussionRARP vs RT plus ADT for Gleason 8 with cribiform and high Decipher
Prostate Cancer | Last Active: Mar 25 5:58pm | Replies (35)Comment receiving replies
Replies to "In Aug '24 I had PSA 14 and biopsy showed Gleason 3+4 cancer. Decipher of 0.90...."
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@larrypt3b I personally agree with your choice of treatment. Even though radiation as a primary treatment has really evolved into an incredible modality, it is STILL radiation.
A very high Decipher score and cribriform cells are known to be somewhat resistant to radiation - even HDR as some on the forum have pointed out and suffered through.
High doses may preclude retreatment in cases where bladder incontinence is a factor (there’s a test for this- the name escapes me).
I will be the first person to say that surgery sucks - even the uneventful kind; but with all those negative factors - and the fact that post surgical pathology can be assessed for the true extent of disease - I would do as you have done and go with surgery as primary treatment. Your SRT should be fairly uneventful - Best of luck!
Phil