← Return to RARP vs RT plus ADT for Gleason 8 with cribiform and high Decipher

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Profile picture for larrypt3b @larrypt3b

In Aug '24 I had PSA 14 and biopsy showed Gleason 3+4 cancer. Decipher of 0.90. Risk class unfavorable intermediate due to % cores positive. PET scan negative for bone and organs. RO suggested different RT's (2 I remember were implanting isotope shards in selected locations in prostate and one that inserted a "tube" to the prostate which was used to localize a much larger dose of radiation fewer times to kill the prostate). Don't know the terminology, but what I do know now is how ignorant I was going in. (I just found this forum; 18 months too late to get these invaluable experiences and viewpoints). Urologist recommended RARP. I chose surgery since I was told RT could be used in case of recurrence, while you couldn't do surgery after radiation. Side effects not bad; no erections (yet?) but no incontinence either. I leak if I'm not paying attention (rare), but no pads since 1st week after surgery. One thing I got with surgery was the prostate tissue and "eyes on" report of conditions around prostate. Things like: Seminal vesicle invasion (SVI) present, bilateral; cribiform glands present; extraprostatic extension present, nonfocal, R&Left posterior; margins negative for invasive carcinoma; and in my case 7 lymph nodes taken all of which were negative. I also was "gifted" with a Gleason downgrade to 4+3, and I got a pT3b and pN0 classification. Extra information although in my case, not great. I was at higher risk of a recurrence due to some of those factors and 18 months later a recurrence has occurred. I see a RO next week to discuss salvage rescue therapies with (no doubt) hormone therapies. I'm sure I'll be back here to discuss what my RO is offering. All in all, I don't regret the choice I made; just the outcome. 🙂 Good luck to you!

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Replies to "In Aug '24 I had PSA 14 and biopsy showed Gleason 3+4 cancer. Decipher of 0.90...."

@larrypt3b I personally agree with your choice of treatment. Even though radiation as a primary treatment has really evolved into an incredible modality, it is STILL radiation.
A very high Decipher score and cribriform cells are known to be somewhat resistant to radiation - even HDR as some on the forum have pointed out and suffered through.
High doses may preclude retreatment in cases where bladder incontinence is a factor (there’s a test for this- the name escapes me).
I will be the first person to say that surgery sucks - even the uneventful kind; but with all those negative factors - and the fact that post surgical pathology can be assessed for the true extent of disease - I would do as you have done and go with surgery as primary treatment. Your SRT should be fairly uneventful - Best of luck!
Phil