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Relapse after BMT

Bone Marrow Transplant (BMT) & CAR-T Cell Therapy | Last Active: Feb 15 2:31am | Replies (31)
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Profile picture for Lori, Volunteer Mentor @loribmt

@jope Welcome to Connect! Well you’ve been through the wringer with two ASCTs and then having CAR-T! Thank you for popping into the conversation.

If you don’t mind sharing a little more about yourself, what led you to requiring the auto transplants? Did you have multiple myeloma?
We have a great discussion for members having had or entering into the CAR-T experience. I’d love for you to enter your story there! Here is a link to: CAR-T Cell Therapy: Introduce yourself and connect with others https://connect.mayoclinic.org/discussion/car-t-cell-therapy-introduce-yourself-and-connect-with-others/

When was your CAR-T? How was recovery?

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Replies to "@jope Welcome to Connect! Well you’ve been through the wringer with two ASCTs and then having..."
jope | @jope | Jan 26 6:52pm

@loribmt Good evening, I was 60 years old when I was diagnosed with IgG Lambda MGUS in February 2015. In May 2017, my M-spike started to rise to 3.0 g/dl., and a bone marrow biopsy showed 85% plasma cells. A fish panel confirmed t(14;16) in 18% of cells, and monosomy 13 in 21% of cells.
In July 2019, my IgG Lambda was .29 g/dl. A fish panel found monosomy 13 in 28% of cells, t(14;16) in 15% of cells and a gain of 1q and loss of 1p in 12% of cells.
In June 2020, a bone marrow biopsy showed 25% plasma cells and 0.3% myeloma cells. Another bone marrow biopsy in November 2020 showed 10-20% plasma cells by morphology and 1% myeloma cells. In December 2020, I had a second Autologous Stem Cell Transplant.
In January 2024, I received treatment with Talvey as bridging therapy. I underwent a CAR-T cell therapy in March 2024. It took me a few years to regain my normal everyday living.
In late September 2025, my Monoclonal IgG Lambda spiked to 0.4 mg/dL and there was an increase in my free light chains. In October 2025, I started Talvey.

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