@tango32652 My inputs would be the same or similar to those provided earlier by @jeffmarc. As mentioned by @jeffmarc, you can discuss with a medical oncologist (PCa specialist) a combination of recent-generation ADT+ARPI medications. The medical oncologist will work with you on the best combination and amount for your specific body. Also, as mentioned by others, a part of the side-effect mitigation now is physical activities which have been shown in studies to be effective. Lastly, depending upon specific side effects, many in this forum can recommend specific techniques that have been effective for them. It often takes persistence with your medical oncologist to find the right combination for you.