Uromune vaccine-Studies from Europe show ~50–70% fewer UTIs, and some women become UTI-free for months to years. Uromune is NOT FDA-approved and not available in the U.S. as of now. It is available in some countries Spain, UK, Mexico, parts of Europe/LatAm.
Evidence is promising but based mostly on non-US studies; larger FDA-style trials are still lacking.

Have you considered or tried Estradiol cream applied to the urethra and vulva? It's very important and often overlooked. After hysterectomy low estrogen increases UTI risk.
Local estradiol keeps the vaginal & urethral tissue thick, elastic, and acidic, which, restores protective lactobacillus, and makes it harder for UTI bacteria to grow or attach. Large studies show ~50% reduction in recurrent UTIs with vaginal estrogen. It’s low-dose, local, and works where the problem is.
I had four UTIs between January and March 2025. Although I was already using vaginal estradiol twice a week, I didn’t notice a real difference until I began applying it nightly to the urethral area and vulva for a couple of months. Since April 2025, I’ve been UTI-free.
I had four UTIs between January and March 2025. Although I was already using vaginal estradiol twice a week, I didn’t notice a real difference until I began applying it nightly to the urethral area and vulva for a couple of months. Since April 2025, I’ve been UTI-free. If your UTI's are triggered by sex you can use a low dose Nitrofurantoin after sex to prevent a UTI. It's also used nightly for frequent UTIs not tied to sex. You are right to be concerned about continuous use of anti-biotic. Non-antibiotic options (D-mannose, methenamine