I had Oorgovyx/zytiga/prednisone testosterone and psa reduction wiped out 2.4 post surgery in 30 days to undetectable. Different people on this site had variations of good-bad side effects. I had increasing fatigue through 20 months when I bailed out of a 24 month regimen to take an adt holiday per md Anderson protocol. Now after 11 increasingly good months psa is .04 up from .01 undectable . One persons experience. Others on here will give better technical reasoning soon .