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Positive ExoDx urine test with negative MRI

Prostate Cancer | Last Active: Jan 25 8:28am | Replies (27)

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Profile picture for derbydog71 @derbydog71

I'm 56 years old, my PSA was 1 in November 2024, in 2025 it was a 2.5 still in the normal range. My main doctor was concerned so they referred me to a Urologist. My appointment was in December of 2025 and they tested my PSA which came back 1.3. They still recommended the ExoDx test which came back at a 27.3. The next step the Urologist gave me was an option of MRI or biopsy. They told me that the biopsy was more accurate then the MRI. I chose to do the biopsy yesterday, January 22nd, 2026. Yes, it was a little uncomfortable, but not terrible. Today I feel pretty good. I'm waiting to hear back with the results which is 1-2 weeks. My prostate was 43 cm3, average is 30cm3-35cm3. I have a lot of cancer in my family, every single relative (4 grandparents and 3 aunts and uncles has died of cancer or have cancer now, except for my paternal grandmother who lived into her 90's). Thanks for all of the posts it really helps a person who is going through the same thing.

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Replies to "I'm 56 years old, my PSA was 1 in November 2024, in 2025 it was a..."

@derbydog71
You really should get genetic testing soon. Were any of those cancer’s breast or prostate or pancreatic cancer? That does increase the chance of a genetic issue. My father died of prostate cancer, but my mother gave me BRCA2 Which resulted me in having prostate cancer at 62. My brother got it 77 because he didn’t have BRCA2 But did have a father that died of it. My mother never had any problems, but both of her sisters had breast cancer, and one of my cousin died of breast cancer.

If a direct relative has prostate cancer, it increases your chance of it by over 100%.

Let us know the results of your biopsy. My first biopsy with a rising PSA showed nothing but the second one showed I had prostate cancer.