← Return to Guidance to help with ADT decision.

Discussion
siems1111 avatar

Guidance to help with ADT decision.

Prostate Cancer | Last Active: Jan 23 12:15pm | Replies (12)

Comment receiving replies
Profile picture for scottbeammeup @scottbeammeup

Not to discourage you from ADT in any way but it's not like other medications in that "six months" doesn't mean six months--it means at least a year because testosterone doesn't return immediately after stopping. I finished six months of Orgovyx in October 2024 and my testosterone FINALLY crossed into low normal (320) in December 2025, about half of what it was pre-treatment. FWIW, my doctor told me my case is an outlier and that most men under 65 recover from Orgovyx in 6-8 months.

However, I did go into the 200 range after about six months which was enough to alleviate some of the worst symptoms, and all my symptoms have since resolved except that it did give me osteoporosis and I'm now trying to decide whether the side effects of a bone infusion drug are worth it for 10% less fracture chance.

Jump to this post


Replies to "Not to discourage you from ADT in any way but it's not like other medications in..."

@scottbeammeup
Just so you have an idea about Testosterone recovery with Orgovyx.

In the HERO study, relugolix demonstrated sustained testosterone suppression superior to that of leuprolide acetate (97% vs 89%; difference 7.9% [95% confidence interval, 4.1–12%; p < 0.001]).

Men (N = 934) were randomized (2:1) to receive relugolix 120 mg orally daily or leuprolide acetate injections every 12 wk for 48 wk.

Overall, 74 of the 137 men in the relugolix cohort recovered to testosterone >280 ng/dl, with a median time to recovery of 86.0 d (95% CI, 65.0–92.0), versus two of the 47 men in the leuprolide cohort, with a median time to recovery of 112.0 d
https://www.sciencedirect.com/science/article/pii/S2588931123002900