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Learned Something New Last Week
Prostate Cancer | Last Active: Jan 26 10:42am | Replies (26)Comment receiving replies
@jc76 Wouldn’t your PSA be suppressed by ADT? Did Proton therapy and my first 3 month PSA came back undectable. As I understand it, it is not necessarily the ‘nadir’. I understood that after I stopped Orgovyx that my PSA level would then reflect the actual nadir. Am I wrong?
Replies to "@jc76 Wouldn’t your PSA be suppressed by ADT? Did Proton therapy and my first 3 month..."
@robertov
One's PSA is definitely artificially depressed while on ADT during and after radiation. It is, still considered your nadir as stated by the 2026 NCCN guidelines.
And you will likely find that once off ADT your PSA will rise.
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@robertov
You are not wrong had dramatic affect on PSA levels and starving PC.
I was originally scheduled to get hormone treatments before my Decipher test came back low risk. My treatment plan then changed from radiation with hormones to radiation only. From my medical doctors ADT starves the prostrate cancer from what it feeds on testosterones.
As I mentioned I did not get hormones so hate to comment on something I did not have. But I just met with my PCP and we went over PSA tests and the decision of medical providers of which PSA test they order depending on what is applicable to the patient.
Per my Mayo doctors and UFHPTI your lowest PSA is common not to see until 2-3 years after treatments end. You like me have a prostate so we are going to have PSA.
In my opinion, and not a medical professional, the lowest point reached probably has a lot to do that your prostate has gone through WWIII and going to be highly irritated for a long time thus not seeing your lowest PSA for years for most.
For you having the PSA at undetectable is great news after at 3 months. If you were on ADT you probably were seeing PSA dropped dramatically even before you got radiation is that correct? My PCP said to me and showed me a graph of PSA after a couple of years is an slight up and down number. The concern comes from an continuous rise every time PSA test is done.
My PSA prior to treatments was 3.75. My PSA test at 3 months was under 1. It then started going down and down and my last PSA at 2.5 years was .12 I am due in April for my next one.
At Mayo Jacksonville my PCP orders traditional PSA test for me and stated that < .10 is undetectable. They do a ultra sensitive test on those who underwent RP.