@vincentjr Hello, I was started on the lowest dose, 72 mcg for two months, no changes at all. Then we tried the larger dose 290mcg which going into second month late summer '25, no discernible change in chronic constipation or bowels. I have continued it to date. I am curious what is the longest time one could expect the Linzess to start making a difference? I am also curious if the Linzess can help with other abdominal discomfort systems?

I have other issues: silent reflux and hiatal hernia. Sometimes where I imagine my stomach is, I have a sense of fullness to the point where I don't want to eat (lost about 15 pounds in a year), rarely also mild nausea. I am fairly careful with what, when, and how much I eat under usual reflux guidelines. Fiber aggravates everything and I have to be careful with that.

In the interim, still continuing the 290 mcg, not long after colonoscopy and upper endoscopy (could be a coincidence) for a few weeks now I have had diarrhea, mostly controlled. I stopped the Linzess just in case and after a week went back to the 72 mcg every other day. I didn't see any changes. Possibly because of the diarrhea I have less discomfort associated with the constipation so ironically feel better because of that and of course, no laxatives needed.

This group has been a solace and when I see the more severe and big lifestyle changes members endure I appreciate I am managing OK and I wish all relief.

I see my GI doctor in a few weeks.