@trk12fire Welcome to Mayo Clinic Connect. Reading about other members' experiences can definitely help allay concerns as we travel our health journeys.

Fluorouracil treatment seems to be a fairly common thing, but there is a wide sweep of reactions to it! My experience is to apply it only to the areas indicated, not all over my face, for example. If there are any hidden spots of concern, they will react to the application. The first time, I thought I was having an allergic reaction, breaking out in angry red areas where no ointment had been applied. Nope, it indicated hidden spots that were responding! Perhaps laying a towel down over your pillow will help? And leave the cream on! Perhaps showering then applying a [very light] amount of ointment. For me, it doesn't take much to produce a response. If you are someone who moves around a lot when sleeping, you might need to adjust that for the next couple of weeks.

Please let me know if there is anything else I can explain to you? And, come back to let me know how you are doing!
Ginger