@crepass Glad to hear you are doing so well on Brinsupri. I can imagine it would be disconcerting to not produce sputum after having been productive for several years. I'd be curious what your doctor thinks. Maybe not an issue unless you have an exacerbation? When's your next CT scan? I'd wonder if you could drop down to 10mg if you go for a while without a flare up.

As for me, I've been in Brinsupri 25mg for a little over 4 months. At the 4 month mark, I saw a significant reduction in sputum, resulting in less time with airway clearance. Yay! So far, I have BE only and leave regular sputum samples. The last time I had a flare and was treated with abx, I was not nearly as ill as I usually get, and got better faster. As of now, I still produce sputum easily. I've had BE for over 2 decades. I still have some early morning coughing (during sleep) but coughing is greatly diminished during the day. When I cough it seems something sets it off and I wonder if it's my asthma. Airway clearance 2x day with 7% saline, mucinex 1200mg 1-2x/day, and mullein tea 5 out of 7 days a week, (I have a giant bag of loose tea to use up!) and daily movement/exercise.