Well it's very strange. Went on an all day trip with hubby. Took two Imodium after I went in the morning. I had no diarrhea for 5 weeks everything was normal. Ate out no issues went on short day trips no problem. Went once a day sometimes even skipped a day. Now it's back again. Gastroenterologist doc said the Immodium was a crutch that reset my mind from worry. She feels I think and worry making it a reality.