@tomrennie
Sadly, I don't remember the ne of the mutation, but it is a known, rare occurrence. The docs know how to adjust the dosing accordingly.

I was on everything available for the nausea, but nothing worked. They stopped the treatment on day 9. It took over a week for me to feel better.

Also, for others suffering from frequent vomiting, my dentist just told me NOT to brush afterwards, but to rinse with water and baking soda to neutralize the acid and protect the teeth. This is especially important for anyone with receding gums.

@tomrennie
I don’t have significant nausea and diarrhea, except a little diarrhea on occasion. I am taking a pre-emotive nausea pill before the temo.

My problems primarily are severe heartburn., abdominal pain spasms in my colon. I also have fatigue.

My primary care dr given me a regimen for taking anti acid meds throughout the day, as well as anti-spasm med. The meds ok’d by oncologist.

Also, instead of taking temo on empty stomach as specialists at Pham suggested, oncologist told me to eat something before taking temo. And that got rid of middle of the night stomach pain after taking temp.

@tomrennie The genetic mutation is called DPYD. I was tested before starting Capecitabine. The test results showed I am an intermediate metabolizer, meaning that Capecitabine is to expected to be metabilized at a level between normal and poor with an increase of toxicity. My oncologist has started me on a lower dosage of Capecitabine, one pill 500 mg in the morning, and the same dosage 12 hours later. So far the only side effect I have had is some fatigue.