@alicebrew1 I used to use Trelegy and when I was at NJH for BE and MABC, the ID Dr and Pulm told me they would like to see me get off it since I got off them once before and due to inhaled corticoids inhibiting the lung immune system. With BE, there is a higher risk of NTM infections with inhaled steroid use. Years ago, I was diagnosed with reactive airway disease (at NJH) and later with asthma (by local Pulm)-which may or may not have been confused with BE. NJH recently retested me for asthma (NOx and methyl choline challenge) and results were negative for asthma. The Pulm there recommended Anoro. Unfortunately, my insurance doesn't cover Anoro, so my local Pulm put me on AirSupra which is short acting, about 4-6 hours. Though, I have now been able to reduce my use of the AirSupra, I would still like to eliminate inhaled steroids completely. My local Pulm has suggested I try Brinsupri to help with the inflammation-among other things, but I'm wondering if that too could reduce immunity in the lungs. I don't know, so interested if that topic has come up.