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Is an ADT Treatment PSA Drop From 25 to 0.63 in 2.5 months Fast?
Prostate Cancer | Last Active: Jan 27 9:34am | Replies (15)Comment receiving replies
ADT shuts down testosterone which feeds prostate cancer growth and can reduce PSA to near zero quickly. The problem is over time the cancer can figure out how to grow around the ADT and PSA begins to rise again. Thankfully there are an array of follow up treatments that can arrest the cancer at least for a while.
Examples include targeted SBRT radiation treatments, chemo regimens and Pluvucto
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@capatov The other recent change is the discovery that starting an ARSI at the same time as ADT for metastatic castrate-sensitive prostate cancer (instead of waiting until the ADT stops working) significantly delays or sometimes even prevents castrate resistance.
The TITAN study demonstrated that (dramatically) for ADT+Apalutamide — to the point that they had to unblind the study halfway through and give the placebo group the opportunity to start on Apalutamide as well.
LATITUDE showed a similar result for ADT+Abiraterone, and there have been successful studies for Enzalutamide and Darolutamide as well.
In the past few years, this new "doublet therapy" has rewritten the book on prostate cancer becoming castrate-resistant in "a couple of years" (as they used to tell us).