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PC treatment: Prostatectomy or Proton Beam Therapy

Prostate Cancer | Last Active: Jan 22 11:40am | Replies (47)

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@charlesprestridge Dr. Cooperberg actually said: "God forbid we would do proton therapy for prostate cancer which should basically never...."

But he clarified this a sentence or two later: "Jason actually ran honest to god RCT of proton versus photon which showed very little difference."

This is what all the experts I've heard who are not enthusiastic about protons say, i.e. the literature so far shows very little difference in outcomes in patients treated with photons or protons.

So the complaint is, the docs see all this money going into building facilities to administer proton therapy, and they see other needs that could have been addressed with that money.

Cooperberg blames the situation on the fact that "We are one of only two countries on the planet that allows direct to consumer advertising in healthcare. It's a travesty. It drives up costs. It drives confusion. It is an absolute mess."

I've seen this in Seattle, the big city nearest where I live. The NCI designated cancer center there invested more than $100 million in a proton facility years ago. It is proven to be better for pediatric cancers among others. But to keep the machine busy, they flood the regional sportscasts with ads touting protons for prostate cancer. When you see a doc there about your prostate cancer they are definitely unenthusiastic about it. Its not that protons are not a good therapy for many cancers, including prostate.

Meanwhile, the RO I see there at my latest appointment replied to my question as to why they don't have an MRI-Linac machine by saying the center won't allocate the $5 million for it.

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Replies to "@charlesprestridge Dr. Cooperberg actually said: "God forbid we would do proton therapy for prostate cancer which..."

@climateguy
Proton radiation costs are going down, and the affects will be felt over the next few years. Instead of having to build buildings for them, they’ve come up with much smaller systems that can fit into one or two rooms. As a result, it’s expected that in a few years (who knows) Proton will be as cheap as photon.

@climateguy Yes, they are planning proton facilities in a couple of Canadian provinces, but they likely won't be available for prostate-cancer patients — they'll be for situations like brain cancer in children, where small margins can have devastating life-long effects (right now, provinces pay to send some of those kids to the U.S. for proton-beam radiation).

As with PSMA-PET scans, there's no evidence that proton-beam radiation improves overall survival or quality of life for prostate-cancer patients: they haven't been able to show that the enhanced technical capabilities actually produce better human outcomes (at least, not yet).

Note that we do have PSMA-PET, but reserve it for exceptional situations, not routine scans.