I had an infusion of Reclast two months ago. It was a studied choice as far as a novice (me) with help from Doctors and boards like this can probably make. I have severe osteoporosis. I am tapering down on Prednisone, but I am still on it (7.5 one day, 5 the next). Prednisone is of course know to cause bone loss. Not my favorite position to be in, but I get the layout on the land on this. On the plus side, my RA said two years on Reclast (one infusion per year) should be enough to protect my bones. All the best in your decision.