@normajean77 I got a Reclast infusion 11 months ago when I was 71, and had a VERY serious reaction. I will never do this again. I continue to have chronic side effects, the worst of which are recurring kidney pain, and serious joint, muscle, and bone pain. I also get recurring headaches, muscle cramps, vertigo, random whole body itching, etc. Like most everyone else, my PC doctor reacted with skepticism about it being caused by the Reclast, but since I was completely 100% healthy with NO issues when I got the infusion, and these symptoms hit like a ton of bricks 16 hours after the infusion, and have continued chronically ever since, I have zero doubts. I have looked, and I can find no real help for this. Studies have been done (posted on the Mayo Clinic site) showing the percentage of time these side effects occur, but I haven't found any answers for when they do. I was looking for how long it stays in your system, for how long this will continue to plague me. So far, here is the only answer I got, and it's not good:
"Reclast (zoledronic acid) stays in your system for a very long time because it binds to bone, with studies showing its effects and presence detectable in bone for many years, even up to a decade or more after treatment stops, though it's quickly cleared from the blood. While the drug's direct effects in the bloodstream are short-lived, its integration into bone means it can continue to work or be released slowly over years, influencing bone remodeling.
How it Works & Stays in Your Body
1. Rapid Blood Clearance: After an infusion, Reclast quickly leaves the bloodstream.
2. Binds to Bone: About half of the drug strongly attaches to bone mineral, effectively becoming part of the bone structure.
3. Long-Term Retention: Because it's incorporated into the bone matrix, it's protected from metabolism and can be released very slowly over many years.
Implications of Long Retention
• Extended Action:
This long retention means Reclast continues to slow down bone breakdown (osteoclast activity) for a long time, providing benefits long after the infusion.
• Drug Holidays:
Doctors may recommend "drug holidays" (stopping treatment) after several years (3-5 years) because the drug stays in the bones, allowing for a break while still getting benefits and reducing risks of serious side effects.
• Detectability:
Other bisphosphonates have been found in urine for years after treatment cessation, showing how long they can persist in the body.
In essence, while you don't feel the drug days after the infusion, its presence and action in your skeleton can last for years."

I am angry that I let my doctor talk me into the infusion, I am angry that I wasn't told or given a medical sheet that listed the potential issues prior to the infusion, I am angry that the drug company doesn't better inform the doctors, but I am mostly angry at myself --- I knew better than to let them put this serious drug in me, but in a moment of weakness, I caved and said okay -- something I will forever regret.