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A cautionary tale for those on ADT: Lupron and Osteoporosis
Prostate Cancer | Last Active: Mar 29 9:27pm | Replies (30)Comment receiving replies
@grandpun
Actually, Lupron has a very short half-life, 3 to 6 hours. If you get a three month shot, As an example, It literally disappears within days of three months.
The problem is that testosterone just doesn’t come back quickly and for some people it doesn’t ever come back. If you’re on Lupron you’re going to wait at least six months to a year for your testosterone to get to a level where you don’t have the side effects from the Lupron. In many cases it takes even longer, 18 months to 2 years to get to 250 or above. There are exceptions, but most people really wait a long time.
Replies to "@grandpun Actually, Lupron has a very short half-life, 3 to 6 hours. If you get a..."
If so many men never recover their testosterone after Lupron treatment, why do doctors keep administering it. If your testosterone never returns why keep beating a dead horse. I only had 4 months of Lupron, but my testosterone is still < 8 after 6 months. I had awful side effects until this seventh month but maybe my testosterone is coming back at age 83 but my nonexistent libido and no erections indicate otherwise.
I have been waiting for 4 years to get my testosterone back. I realize it is probably my age (88). @jIeffmarc
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@jeffmarc
Yeah Jeff, this hits on the fine line between the presence of Lupron vs it's effects.
Chart attached shows 3-month interval injections but suppression of T is relatively constant due to the "steady state release" of Lupron in the bloodstream based on the concentration when it's administered. (Details here. Item 12.3 :
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf)
Lupron may be largely out of one's system but its effects, particularly to testosterone suppression as in mine and other's cases, continue. Possibly for much longer. My GU/oncologist also says this persistence of side effects increases with age. I was 76 when Lupron was started, 78 when concluded; I may be dealing with this for a while longer.
Thanks for your comments.