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Methotrexate and Kevzara are both approved to treat PMR. Unfortunately both of them can take up to 3 months to take full effect. Kevzara is a self-injection you take every 2 weeks, and methotrexate comes in pills. I take Actemra, which is a biologic drug similar to Kevzara, and I haven't had any side effects from it in a year and a half. I think methotrexate might have more side effects, but it works well for some people.

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Replies to "Methotrexate and Kevzara are both approved to treat PMR. Unfortunately both of them can take up..."

@jeff97 I was offered methotrexate. I was not familiar with it. I am not the type of person to take a medication unless I have full knowledge about it. Of course doctors try to explain the difference between prednisone and methotrexate but they are busy and don’t have time. That day I was desperate for something to relieve the pain. I am in Canada and I do believe that KEVZARA has been approved by our fda recently. Yet the family doctor was not aware of it. Nor the nurse practitioner who works with the doctor. I am allergic to so many medications that I am interested in hearing more about this medication. I am allergic to antistetics. Not all but the main ones. It’s a redhead thing apparently! lol. The issue again is waiting for the rheumatologist to see me and then she will be able to make the call on the medication. I have experienced pain before but never anything like this. The prednisone at the higher dose was starting to show positive signs but the side effects were horrible and not safe in my case. My mother didn’t respond well either. When she took them for another reason. I remember laughing at her when she had hallucinations. Now I know what she went through and it’s not nice . I would do anything to have her back to tell her how sorry I was for laughing. In a joking way of course. My children were laughing at me of course! I just pray that I find the kevzara is the best for me. I normally have a high tolerance for pain. This is an all day long thing that doesn’t really slow down at night.

@jeff97

I'm glad you seem to be responding to Actemra. I think Prednisone is a good bridge to better treatment options. I have some unpleasant memories of methotrexate but it does work for some people.

Fortunately prednisone isn't the only option anymore. However, we still need to figure out what bridge to take to a better treatment. That seems like it is only done by the trial and error method.