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PC treatment: Prostatectomy or Proton Beam Therapy

Prostate Cancer | Last Active: Jan 22 11:40am | Replies (47)

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With my contained 3+4 case and high Decipher of 0.81, I looked at the situation much like @brianjarvis and also chose radiation as the side effects of an RP are pretty severe and immediate.

Some would say that as your odds of recurrence increase from having high risk factors like high Gleason scores, high Decipher score, intraductal, cribriform, PNI, seminal vesicle invasion, EPE or ECE then surgery is the better option because wide area radiation is still available to use if a recurrence happens. The counter to that is whether you think you could use radiation initially to get a clean wipe of all cancer both in the prostate and the greater pelvic region. Your best odds on doing that with radiation is to use a combination of something like 26 IMRT sessions (wide area radiation) and one SBRT or HDR brachytherapy session as a boost to the prostate. If your risk factors are low, you can also use a less aggressive radiation plan like 5 SBRT sessions and have low odds of recurrence. But as your risk factors go up, then it becomes harder for either radiation or surgery to have low odds of recurrence and the decision on surgery or radiation becomes all the more difficult.

If you and your doctors can come up with a radiation treatment plan that you believe has low odds of recurrence, then that approach will be the easiest to endure. If you have a recurrence after a primary radiation treatment then you will only have spot radiation like SBRT available to use again. But if you and your doctors believe that recurrence is almost inevitable after any initial treatment then surgery as the initial treatment leaves you both IMRT (wide area) and SBRT spot radiation available to attack a recurrence. Of course, there are drugs that can be used to fight a recurrence whether the initial treatment was surgery or radiation.

For me, I felt optimistic that an aggressive radiation plan could keep my recurrence odds low so I went with radiation over surgery. And so far so good. See my bio for more details.

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Replies to "With my contained 3+4 case and high Decipher of 0.81, I looked at the situation much..."

@wwsmith Actually, if there is local recurrence after initial radiation, choice of salvage treatment would depend on the nature of the recurrence; there are other options —> focal therapy (e.g., cryo), brachytherapy, and SBRT (because those are all very targetable), and yes even re-radiation in some cases. I personally know two guys who had their prostate recurrence re-treated with SBRT, because the recurrence was a single spot. (Plus, these days there are systemic treatments for recurrence - Isotope therapies, Immunotherapies, Checkpoint Inhibitor therapies, and PARP inhibitor therapies. So many secondary options.