I started on Tagrisso about a month ago after about 2.5 years on Tarceva after being diagnosed with stage 4 lung cancer (metastises on in lungs at this time). So far I think there are fewer side effects than Tarceva except that I feel a lot more tired (which might not be the Tagrisso, of course). My skin is still dry, nails still pathetic, but I have a bit more appetite and don't have such bad diarrhea. There hasn't been enough time to see if my hair returns to normal (it went extremely curly/frizzy - a bit like Beethoven or Einstein!) but I have great hope! Best wishes to you all.