@pesquallie
The thing with low testosterone not working is that it does work even in aggressive cases at the beginning, but as they become more aggressive, the cancer cells can grow even without it. That’s when they try to use BAT and give high doses of testosterone,

@pesquallie Also remember that early studies (AI or otherwise) are just signposts for promising paths to explore. New treatment modalities need to survive several phases of major trials to become standard of care, and frankly, the vast majority don't make it: they can't be reproduced, or the cause is demonstrated to be something else, or the positive effects don't hold up over time, or negative effects emerge.

That said, we've seen some recent research blossom into well-supported changes in how we're cared for. Many oncologists are already treating oligometastatic cancer with curative intent, for example, and that may soon become universal.

But a single study doesn't change anything, as study authors would be the first to tell you. And be especially careful of confirmation bias, cherry-picking individual studies to support what you already want to believe.

From a personal PoV, I have to say that the effect of over 4 years of ADT and Apalutamide on my stage-4 oligometastatic cancer has been little short of miraculous: I feel like I've had a death sentence commuted, and am planning for old age again instead of putting my affairs in order, like I was in 2021. YMMV.