Prostate cancer goes dormant, What really happens?

Posted by jeff Marchi @jeffmarc, Jan 11 6:50pm

Here is an article I just received today that discusses the issue of prostate cancer going dormant, with quite a good amount of detail.

It also discusses some scary things that can bring it back.
https://www.nature.com/articles/d41586-025-04149-3

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for ededed @ededed

Thank you for alerting me to this article. It was great to read that research into cancer stem cells is moving forward. For a while now, I have been reading about the ability of Turkey Tail mushrooms to cause the death of prostate cancer stem cells. I have felt that western modern medicine has been slow to recognize mushroom medicine's ability to work with modern medicine (surgery and radiation) to reduce the reoccurrence of various cancers (prostate, breast, colorectal and a few others). Here's an article that set me thinking along these lines:
https://journals.plos.org/plosone/article

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@ededed Ed, you are a great resource for the mushroom supplements; I use 1 gm Turkey Tail every day for immune support since some of my WBC’s are still sub-par…but did want to mention that the large study out of Japan, which recommended Turkey Tail as a supplement to chemotherapy in GI and breast cancer, used between 3 and 9 grams per day!
That is an awful lot to take on a daily basis if it’s being used prophylactically to keep recurrent PCa at bay.
I don’t think it’s necessarily harmful, but it would definitely hurt your pocketbook as the stuff is not cheap.
I think a lot of alternative medicine glosses over the fact that herbs, botanicals and the like have to be taken in extreme quantities to maybe be effective at all. Purified or concentrated formulas might offer NO benefit at all since chemical alteration totally degrades whatever other components are inside the herbs to enhance absorption…just sayin’
Phil

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Profile picture for heavyphil @heavyphil

@ededed Ed, you are a great resource for the mushroom supplements; I use 1 gm Turkey Tail every day for immune support since some of my WBC’s are still sub-par…but did want to mention that the large study out of Japan, which recommended Turkey Tail as a supplement to chemotherapy in GI and breast cancer, used between 3 and 9 grams per day!
That is an awful lot to take on a daily basis if it’s being used prophylactically to keep recurrent PCa at bay.
I don’t think it’s necessarily harmful, but it would definitely hurt your pocketbook as the stuff is not cheap.
I think a lot of alternative medicine glosses over the fact that herbs, botanicals and the like have to be taken in extreme quantities to maybe be effective at all. Purified or concentrated formulas might offer NO benefit at all since chemical alteration totally degrades whatever other components are inside the herbs to enhance absorption…just sayin’
Phil

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Someday I should weigh the amount of Turkey Tail that I take daily. I take
a rounded 1/2 teaspoon of the Host Defense powder and the same amount of
Lion's Mane. Or, I make tea from Turkey Tail mushrooms that I collect in
the local woods. While chemical alteration and processing does alter the
preparation there are two other considerations. One is that whole foods,
herbs, mushrooms, may have benefits greater than the extracted target
chemical. Also, sometimes cooking or heating improves the bioavailability
of the desired nutrients or chemicals. (Such as broccoli. etc)

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I checked and found some bulk powder, and that Turkey Tail does not contain the nasty mycotoxins present in other mushrooms. It worked on the mice and human cells in a petri dish, so I'll give it a try for one month, prior to my biopsy and report back here.
Sam

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Profile picture for ededed @ededed

Someday I should weigh the amount of Turkey Tail that I take daily. I take
a rounded 1/2 teaspoon of the Host Defense powder and the same amount of
Lion's Mane. Or, I make tea from Turkey Tail mushrooms that I collect in
the local woods. While chemical alteration and processing does alter the
preparation there are two other considerations. One is that whole foods,
herbs, mushrooms, may have benefits greater than the extracted target
chemical. Also, sometimes cooking or heating improves the bioavailability
of the desired nutrients or chemicals. (Such as broccoli. etc)

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@ededed

Antioxidants in mushrooms are so strong that heat does not effect them. It does not make them more available but it does not effect them in negative way- they are so amazingly stable and that makes them such strong anti-oxidant.

On the other hand, some studies suggest that mushrooms are preferably treated with heat since heat removes some compounds such as agaritine which in high doses can actually be harmful ( at least with mice studies). Agaritine is present though only in Agaricus genus (white button mushrooms and Portabello, etc) .

Happy shrooming : ))) !!!

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Profile picture for surftohealth88 @surftohealth88

@ededed

Antioxidants in mushrooms are so strong that heat does not effect them. It does not make them more available but it does not effect them in negative way- they are so amazingly stable and that makes them such strong anti-oxidant.

On the other hand, some studies suggest that mushrooms are preferably treated with heat since heat removes some compounds such as agaritine which in high doses can actually be harmful ( at least with mice studies). Agaritine is present though only in Agaricus genus (white button mushrooms and Portabello, etc) .

Happy shrooming : ))) !!!

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@surftohealth88 I'll have to look into agaritine. I am very allergic to raw mushrooms. I'm fine with cooked mushrooms. Could it be the agaritine? More for me to research.

Two chemicals that have been found to be anti-cancer in Turkey Tail mushrooms are PSK and PSP, both are polysaccharides. They are not affected by heat or apparently stomach acid. They work their magic in the large intestine.

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I was shut out before the article ended (didn't subscribe) , but the information is very interesting. When my radiation oncologist declared that he wanted to treat the cancer "so it never comes back" but that the PSMA PET scan showed activity in two lymph nodes adjacent to the prostate, I countered with a personal observation. I live in Texas where we deal annually with Yellow Jacket nests around the eaves of our homes. I pointed out that every time I spray a nest, one or two YJs escape and I find them building a new nest a few days later. Since my lymph node tumors had access to the body's "interstate," I fully expect that a few cancer cells are around the body somewhere. They're dormant while hormone therapy is keeping them ducking their mutant heads but they'll eventually awaken and resume multiplying at some point after treatment ends. I'm grateful that prostate cancer treatment isn't "one and done" but that there are a number of options along the way. At 74 and without a family history of longevity, I don't expect I'll use up all the options, and new ones are rapidly being developed.

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Profile picture for jime51 @jime51

I was shut out before the article ended (didn't subscribe) , but the information is very interesting. When my radiation oncologist declared that he wanted to treat the cancer "so it never comes back" but that the PSMA PET scan showed activity in two lymph nodes adjacent to the prostate, I countered with a personal observation. I live in Texas where we deal annually with Yellow Jacket nests around the eaves of our homes. I pointed out that every time I spray a nest, one or two YJs escape and I find them building a new nest a few days later. Since my lymph node tumors had access to the body's "interstate," I fully expect that a few cancer cells are around the body somewhere. They're dormant while hormone therapy is keeping them ducking their mutant heads but they'll eventually awaken and resume multiplying at some point after treatment ends. I'm grateful that prostate cancer treatment isn't "one and done" but that there are a number of options along the way. At 74 and without a family history of longevity, I don't expect I'll use up all the options, and new ones are rapidly being developed.

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@jime51
Actually, I didn’t subscribe either, but there was a download button and if you download you get the whole thing.

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during my greenlight surgery dormant cancer was found. I recently had my PSA test done. After the greenlight surgery my PSA dropped to .47 it was 12.4 before the procedure. The doctor informed me if my PSA reach 2.0 the cancer has become “alive” at my age of 72 he told my buntley I would 10 years before the cancer spread and kill me.. I have to have my PSA test once a year. NOTE: the PSA results are not validate it with a urine sample. Blood was taking from my arm for the PSA TEST.

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Profile picture for rich9164809 @rich9164809

during my greenlight surgery dormant cancer was found. I recently had my PSA test done. After the greenlight surgery my PSA dropped to .47 it was 12.4 before the procedure. The doctor informed me if my PSA reach 2.0 the cancer has become “alive” at my age of 72 he told my buntley I would 10 years before the cancer spread and kill me.. I have to have my PSA test once a year. NOTE: the PSA results are not validate it with a urine sample. Blood was taking from my arm for the PSA TEST.

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@rich9164809
Blood is almost always taken from the arm for a PSA test. I’ve done it that way for eight years. Your doctor may or may not be correct, if you read the article that I posted you will find that dormant prostate cancer becomes active due to things that happened to you. Your doctor may be right that when it hits 2.0 that means it has become alive already and that’s why it rose up that high. If that happens, they can put you on ADT and an ARPI and you could last another 10 or 15 years With those currently available treatments and whatever else comes out new, by the time you have it reoccurr. This is definitely not the time to start worrying. You might read the full article since you have been told you have dormant prostate cancer, and that will give you More information.

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Profile picture for rich9164809 @rich9164809

during my greenlight surgery dormant cancer was found. I recently had my PSA test done. After the greenlight surgery my PSA dropped to .47 it was 12.4 before the procedure. The doctor informed me if my PSA reach 2.0 the cancer has become “alive” at my age of 72 he told my buntley I would 10 years before the cancer spread and kill me.. I have to have my PSA test once a year. NOTE: the PSA results are not validate it with a urine sample. Blood was taking from my arm for the PSA TEST.

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@rich9164809 How does your doctor know the cancer is dormant? By what metric?
Certainly your PSA was high enough before laser surgery to warrant a biopsy; and that biopsy would have come with a Gleason Score. In fact, you cannot know if cancer exists from a Green Light Laser because all the tissue is vaporized and can’t be biopsied so I don’t know how your doc is able to make any statement at all.
I had GLL done with a PSA of 4.0 due to cystoscope showing large peduncle (like a mushroom) in the medial lobe protruding into the bladder.
“Cancer doesn’t look like this” she said and did the procedure, giving me tremendous relief from BPH.
Six years later, after being diagnosed with extensive Gleason 4+3 cancer, my surgeon said I probably should have been biopsied BEFORE doing the Green Light since it could have been cancer and it could have been addressed earlier…
Yes, a lot of couldas and shouldas in hindsight, but I just don’t see what your urologist is talking about when he mentions ‘dormant’ cancer…
Phil

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