@srvtexas My thoughts alone: Each person will make their decision based on their age, where you are in efforts to raise a family, diagnosis, prognosis, and your quality of life before and after trying Anastrozole. If younger and still with young or teenage children to raise, I might have tried to tough it out. But, being 83, no young dependents, and an otherwise good outlook on my remaining life, I chose quality of remaining years vs. the side effects which worsened existing back pain and brought back depression. Don't need that!