@lala56 Thank you for sharing what side effects you are experiencing on Tagrisso. I have also noticed a couple of little cracks in the skin on my hands recently and will load 'em up with moisturizer. Aside from swelling around the ankles and a slight rash in that area, as well, I don't feel sick. The problems I had in the beginning of not being able to swallow easily and no appetite have passed. Now I need to make sure that I'm eating nourishing food and not just consuming calories to keep from losing weight. One of the things I have each morning is my Metamucil - 2 tablespoons of powder dissolved in a cup of water. That way, I'm not straining to poop and the bowel movement comes out much easier. Plus, Metamucil has psyllium husk that helps lower LDL cholesterol, which I've been working at. So far, so good. You sound like you have a fine medical team, and that means so much with what you're going through. Don't you just want to hug them all? Take care. All the best to you with your care.