My husband has been on Orgovyx and Nubeqa for 5 months and they are working well so far. His situation sounds very similar to your husband’s. His info. is in my profile if you’re interested. His only side effects of the treatment have been hot flashes and a bit of fatigue, nothing that keeps him from doing normal activities or has affected his health otherwise. We requested the Orgovyx/Nubeqa combo right at the start and had no problems getting either of them. Nubeqa has a co-pay program which requires one payment of $300 and then no more co-pays for a year. Our Blue Shield covers the Orgovyx. My understanding is that both of these drugs are newer and are therefore more expensive but they are much better than the older ones in terms of side effects. Maybe you should ask your doctor for a more detailed explanation of why she won’t prescribe this drug combo. We had no problems getting them through our UCLA oncologist.