I take them in the morning after breakfast - not sure which is best. My latest scan shows that I am getting good results as the statement from the PA who reviewed the scan results says "the problem is resolved" - I still have a mucus problem but the lower lobe of the right lung has cleared out and the mucus keeps coming out. Unfortunately, MAC is incurable, but as long as a simple treatment works I am thankful. I am not the least interested in the "big 3" due to a horrible allergic reaction to antibiotics,