My hubby is on Nubeqa and Orgovyx for his stage 4 PC. He has very few side effects from this combo. Very occasional hot flashes and some fatigue. Since he previously had a heart attack 8 yrs ago, he does get monthly EKG's to monitor him for Long QT syndrome. He has been on this regimen for 8 months now and after 6 cycles of Docetaxel, he is currently in "remission". I might add we had to fight for the Orgovyx over Lupron. Oncologist said "Insurnace isn't going to pay for that" and I told him we weren't going to go with that answer without checking into it first. Low and behold insurance pays for it. After many issues with that Onco, we now have a new one that listens to us better. But the new one even said "Your my only patient on Orgovyx". I asked why but he didn't have an answer outside of that's how we've always done it.