My gynecologist felt that it was "ok" for me to embark on a 'late start' with HRT. So I tried what he considered "a low dose" ----I swelled up like a balloon (especially notable in my face), became quite moody & overall, simply felt sick--------BUT, that was my experience----- Low-dose HRT helps some of us 'older' women. ( I'm disappointed I can't be one of them.)