@denis76
I attend weekly advanced prostate cancer meetings at ancan.org. There at least 10 people there that are on Nubeq Alone. It works quite well to suppress testosterone so you don’t need ADT with it. That works for a lot of people, but not everyone. Some people do need ADT for testosterone suppression. I am one of them.

I’ve been on ADT for eight years, I’ve been undetectable for 26 months. Maybe I’m an exception, but in my case, at least the lack of testosterone has not made my cancer worse, yet.

There are issues with low testosterone. Some of the prostate cancer cells can become immune to low Testosterone and start to grow even in that environment. In those cases, some doctors have used BAT to give people high doses of testosterone, which then kills off the cells that have become capable of growing, even though they don’t need testosterone. It’s a strange solution, but it does work for some people. I gave you a link to an article about that, Not sure you were able to read it, but it also talked about mutations and advanced prostate cancer. Some really interesting articles.

By the way. I disagreed with your doctor that Nubeqa working better with BRCA2 to suppress prostate cancer. I did some research on this, and it actually appears to be true, though Xtandi (Enzalutamide) also works well with BRCA2 while Erleada does not appear to have the same benefit. Apparently, ATM does not have the same advantages.