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← Return to treatment options for paratracheal lymph nodes with BRCA2
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treatment options for paratracheal lymph nodes with BRCA2
Prostate Cancer | Last Active: 2 days ago | Replies (19)Comment receiving replies
@jeffmarc Thank you. This "ADT holiday" is just that, and I am planning on getting back on ADT*. Last time around I did Eligard and Zytiga and it worked out just fine, the drugs knocked back 25+ lymph nodes with a PSA of 19 to less than 0.1 within 4 months. What isn't clear to me is the rationale of why I would even consider radiation. These new lymph nodes are different from the previous ones, so to your point, with BRCA2, I think it is a losing proposition to take a whack a mole approach, I think I just need to do long term ADT. My team has expressed interest in a PARP, we are meeting on Wednesday. Will report back
Replies to "@jeffmarc Thank you. This "ADT holiday" is just that, and I am planning on getting back..."
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@edmond1971
The problem with depending on the drugs to handle actual Metastasis is not a long-term solution. The drugs will not last for the long-term and your PSA will start to rise, even though you are on them, and the metastasis will start to grow. Your SUVs were very low so you may not want to even do anything at all about them.
I can’t imagine getting off ADT and having my PSA rise to 19. That just is not careful planning. I know people who have BRCA2 and have gone on vacations and other people who do not have it but are Gleeson, nine who have gone on vacations, and in all these cases, their metastasis have increased dramatically after a second or third vacation. Sounds like a great idea, but it has not worked out well for people I know. I attend nine advanced prostate cancer online meetings every month so I hear from a lot of people.
As for the PARP inhibitor. My oncologist has discouraged my getting on a PARP inhibitor Until the other ADT and ARPI drugs stop working. There’s good reasoning behind this. I didn’t disagree with her because I was paid to review Akeega documentation. That drug includes a PARP inhibitor with Zytiga. The warnings In the documentation, Which my oncologist referred to, We’re pretty eye-opening. The PARP inhibitor causes serious problems with your blood. RBC, WBC and platelets tests can be dramatically reduced resulting in people needing blood transfusions because they are so anemic. It also can cause high blood pressure.
These are things to discuss with your doctors before going on a PARP. I’m staying on ADT and Nubeqa Until it stops working. Then I will take a PARP.