@lss111
1. Has Brinsupri significantly improved your lung function, decreased flares and when you began to improve? No PFTs yet since starting Brinsupri 4 months ago. Feel better overall, more energy. Most days less sputum.

2. I read it may take 4-6 months for approval- experience with approval process, has anyone been denied? Mine took around 1 month.

3. I am concerned about serious side effects. (everyone is!)
Skin - Literature/trial data show there's an increase in SCC, BCC (non-melanoma skin cancers) in those taking 25mg Brinsupri [less than 1 person per 100]. I've had to move up my derm check as there are a couple of spots I want checked. Being cautious and conservative. I see derm 2x year as I've had lots of UV exposure and have fair skin. If SCC or BCC diagnosed will move up to 4x year checks. Hard to know if they are related to Brinsupri. These skin cancers are very very common in older adults.
Hair loss- none that I am unaware. Hair naturally thins with age anyway.
Dental- Take good care of teeth with twice a day brushing, flossing and fluoride rinse. Early gum disease is reversible.

My advice: try it you can always stop it. It's the ONLY FDA approved treatment for bronchiectasis, documented to slow progression.