Positive vibes: I have been on Tymlos for two years, with great results. At the start, my spine was -3.7, femur neck -3.7, hip -3.5. My latest DXA: spine -1.8 (!!!), femur neck -2.7, hip -2.5. I am thrilled with the results -- even the femur neck close to osteopenia instead of osteoporosis. I had chosen Tymlos over Forteo because I travel a lot and feared I wouldn't be able to keep Forteo refrigerated, as required. Still, I was really terrified of taking Tymlos because of reported side effects. But all went well. Minimal side effects (just brief increase in heart rate), no hassle with injections. I will now go on Fosamax for 1 year (I am hoping!) to ensure no new bone gets reabsorbed and hope to gain some new bone in my hip and femur neck. Tymlos is not supposed to work as well the second year (even the drug company's own website shows this), but that was not my experience. I had just as good results the second year. I have been exercising regularly (treadmill for the impact that is supposed to help bone grow plus weight lifting for strengthening) plus having lots of calcium (I am a milk drinker, so that is easy). Perhaps that helped improve my results. Anyway, just sharing the good news for those who are fearful, as I was, of all these OP drugs.