← Return to The right time to start radiation post RP with an increasing PSA?

Discussion
Comment receiving replies
Profile picture for jeff Marchi @jeffmarc

@sriddle1
The problem is he does have an aggressive case of prostate cancer and, it is not a very big rise in PSA. The question is, does his case fit into the below guidelines for why someone should have Adjunct radiation, And not wait until PSA hits .2 for salvage radiation.

I know his Gleeson score is a nine so that hits one of the risk factors. Does he have one other of those below listed Risk factors?

I think this is something that @surftohealth88 Also was looking into. Maybe she can comment about why they decided to wait.

Adjunct radiation
Dr. Efstathiou concluded as follows:
* Early salvage radiotherapy is favored over adjuvant radiotherapy in most patients
* Consider adjuvant radiotherapy in otherwise fit, motivated, very high-risk patients with ≥2 of the following risk factors:
* pT3b-4
* Gleason score 8-10
* pN+ Lymph node Metz
* Decipher score >0.6
* In high-risk patients, use lower thresholds to initiate ‘ultra-early salvage or adjuvant-plus’ radiotherapy
* If giving adjuvant radiotherapy, it implies high-risk disease. Thus, Dr. Efstathiou would recommend treating the prostate bed and pelvic lymph nodes, in addition to short-term versus long-term ADT, depending on risk factors
* May consider genomic classifiers or artificial intelligence tools to help with informed decision-making
* The goal is to avoid (or delay) radiotherapy in those who we can, without missing a window to cure patients who are guaranteed to recur

Here is a link to the article supplied by @surftohealth88 originally
https://www.urotoday.com/conference-highlights/apccc-2024/151546-apccc-2024-debate-how-to-best-manage-a-fit-patient-with-high-risk-localised-and-locally-advanced-prostate-cancer-how-to-select-patients-for-adjuvant-therapy-after-radical-prostatectomy-and-how-to-treat-them.html

Jump to this post


Replies to "@sriddle1 The problem is he does have an aggressive case of prostate cancer and, it is..."

@jeffmarc thank you Jeff. I will read the link you sent and thank you for pointing out the important information on your reply.

I guess we’ll be starting this journey of more treatments.

Thank you