← Return to The right time to start radiation post RP with an increasing PSA?

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@jeffmarc with more aggressive features as my partner has, MO recommended to us yesterday at our first appointment to have him start Zytiga and Orogyx straight away and most likely 7 weeks of radiation. His PSA yesterday was 0.076 up from a month ago 0.072.

Would he want to wait a bit or start straight away because of the aggressive features his PCa has? Thank you

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Replies to "@jeffmarc with more aggressive features as my partner has, MO recommended to us yesterday at our..."

@sriddle1
The problem is he does have an aggressive case of prostate cancer and, it is not a very big rise in PSA. The question is, does his case fit into the below guidelines for why someone should have Adjunct radiation, And not wait until PSA hits .2 for salvage radiation.

I know his Gleeson score is a nine so that hits one of the risk factors. Does he have one other of those below listed Risk factors?

I think this is something that @surftohealth88 Also was looking into. Maybe she can comment about why they decided to wait.

Adjunct radiation
Dr. Efstathiou concluded as follows:
* Early salvage radiotherapy is favored over adjuvant radiotherapy in most patients
* Consider adjuvant radiotherapy in otherwise fit, motivated, very high-risk patients with ≥2 of the following risk factors:
* pT3b-4
* Gleason score 8-10
* pN+ Lymph node Metz
* Decipher score >0.6
* In high-risk patients, use lower thresholds to initiate ‘ultra-early salvage or adjuvant-plus’ radiotherapy
* If giving adjuvant radiotherapy, it implies high-risk disease. Thus, Dr. Efstathiou would recommend treating the prostate bed and pelvic lymph nodes, in addition to short-term versus long-term ADT, depending on risk factors
* May consider genomic classifiers or artificial intelligence tools to help with informed decision-making
* The goal is to avoid (or delay) radiotherapy in those who we can, without missing a window to cure patients who are guaranteed to recur

Here is a link to the article supplied by @surftohealth88 originally
https://www.urotoday.com/conference-highlights/apccc-2024/151546-apccc-2024-debate-how-to-best-manage-a-fit-patient-with-high-risk-localised-and-locally-advanced-prostate-cancer-how-to-select-patients-for-adjuvant-therapy-after-radical-prostatectomy-and-how-to-treat-them.html