@songinmyheart54: welcome to Mayo Clinic Connect. Since I wrote that post in November of 2024, I have become actively involved in this forum becoming one of the mentors who assists with fielding questions such as yours. Additionally, as a patient I had a successful initial course of Keytruda as my solitary metastatic lung nodule resolved within the first three months of treatment. Due to other issues, which I’ll detail in a later post, I’ve since had to discontinue immunotherapy earlier than anticipated.

Keytruda affects people differently and it can cause a variety of adverse reactions. I’m not certain I understand your treatment plan correctly as I’m unfamiliar with remaining on Keytruda beyond two years. If you are staying on it indefinitely, have you discussed the rationale for this? Do any of the providers oversee your home monitoring results?

As you noted, vital signs such as heart and respiratory rate as well as oxygen saturation change with activity. If you’re noticing a decline in your breathing, additional testing could be performed to assess this.

It sounds like you’ve attempted to discuss these concerns with the providers with whom you’ve been treating. Can you tell me if they’ve tried or suggested any interventions to assess the changes as you’ve described? For example, have you had pulmonary function tests or cardiopulmonary exercise testing?