I had to stop taking Tagresso 2 1/2 years ago. I took it & was fine for about 8 months. All of a sudden I got very sick. I might have been allergic to something. I still get a CT scan every 3 months. If you have to go off Tagresso for any reason, there are so many medicines that are available. I am not on any medication & in remission. You can be fine without it. Hugs!!