Creon - am I taking too much or too little?

Posted by stillaround @stillaround, Sep 27, 2025

Hi - pancreatic cancer person here. (Surgery 14 years ago removed tail, recurrence on head a year ago, currently in remission after treatment including hi-dose radiation.) Started Creon several weeks ago. I THINK I am taking enough as I am finally putting weight on, stools are proper color etc. But I am quite bloated with distended belly and a bit constipated. If everything else is good could this mean I'm not taking enough? Or does constipation with normal stools mean I'm already taking too much?

I take 36,000 with my smallish calorie-dense meals, my weight is 108. The PERT calculator indicates I need closer to 48,000 at breakfast but other meals I'm in range.

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I have been on Creon for nine years, and I still need to make frequent adjustments to the dose because it depends on what you eat.

My initial prescription was for three 24,000 capsules units at each meal, but I usually take one capsule. You know you didn't take enough when you get steatorrhea (loose stools, etc.) because of malabsorption of the fats you consume.

A few months ago I read an article in a national newspaper written by an endocrinologist: she advocates, and takes herself, psyllium multiple times a day. I think it helps, but apparently it can worsen pancreatic enzyme insufficiency. We are all different and trial and error seems inevitable with Creon.

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Recently prescribed Creon. I am 66 female weight 195 - nearly impossible for me to lose belly fat. Struggling with how much & when to take Creon
Anyone else have similar reason for being prescribed Creon and what the correct dosage should be?

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Profile picture for allioops @allioops

Recently prescribed Creon. I am 66 female weight 195 - nearly impossible for me to lose belly fat. Struggling with how much & when to take Creon
Anyone else have similar reason for being prescribed Creon and what the correct dosage should be?

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Have you checked with the prescribing physician or his medical team yet

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Hello! I take Qty. (2) 12,000 Units with my dinner only. My breakfasts and lunches tend to be small and lower in fat. My dinner is my largest meal and the one that can have more fat although I try to stay with fish, chicken, and turkey most of the time.
If I have a higher fat meal, I can tell that Qty. (2) is probably not enough and could benefit and take an additional Creon as I become bloated and gassy. Otherwise, I go by how I feel (gassy or not) and the look and frequency of my stools. Prior to starting on Creon, I has very, very gassy, bloated, and very soft stools. My weight has been holding steady at 168 to 140 lbs.

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Profile picture for gravity3 @gravity3

Have you checked with the prescribing physician or his medical team yet

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@gravity3
My surgeon sent the prescription to creon. I take 2 large capsules at meals and 1 capsure at snack. If I don't take the creon at a snack my stool is clay colored. And I lose weight.

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Profile picture for allioops @allioops

Recently prescribed Creon. I am 66 female weight 195 - nearly impossible for me to lose belly fat. Struggling with how much & when to take Creon
Anyone else have similar reason for being prescribed Creon and what the correct dosage should be?

Jump to this post

@allioops Optimization of Creon is easily accomplished using the dosing calculator at pertcalculator.org. The site also has information on taking the first capsule at the beginning of the meal and staggering capsules throughout the meal when additional capsules are required.

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I also wonder if I am taking too much creon. I have lots of painful gas and bloating all the time. What does this mean? It has been 3 months since the whipple.

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Profile picture for allioops @allioops

Recently prescribed Creon. I am 66 female weight 195 - nearly impossible for me to lose belly fat. Struggling with how much & when to take Creon
Anyone else have similar reason for being prescribed Creon and what the correct dosage should be?

Jump to this post

@allioops always take Creon immediatly before food. i take 9 25000 strengh with all food, if i have a coffee or a sweet i take 6. if half an hour lapses between meals i would take another 6 to 9. you cant overdose on them. if your poo floats or its lighter than the colour of dark chocolate i would increase creon.

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Profile picture for anilittl @anilittl

@allioops always take Creon immediatly before food. i take 9 25000 strengh with all food, if i have a coffee or a sweet i take 6. if half an hour lapses between meals i would take another 6 to 9. you cant overdose on them. if your poo floats or its lighter than the colour of dark chocolate i would increase creon.

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@anilittl are you having cramps with too much creon?

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I also had constipation with Creon. When that happened, I took one capsule of stool softener and it worked. Or I skipped the Creon. It was a balancing act for sure!
Your MD is the only person to address the amount of Creon.

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