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Anyone have testosterone replacement therapy (TRT) after ADT?
Prostate Cancer | Last Active: May 16 11:28am | Replies (82)Comment receiving replies
@retireddoc
Thank You for your post.
I understand, if I go on TRT, I have to be on it for the rest of my life because Pituitary gland stops signaling to produce T naturally. Is that true? Don't I have to stop TRT if my PSA keeps raising at some point? Does it mean I will be on TRT intermittently?
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@ava11
Please let me preface this reply that nothing I may say takes the place of discussion with your treating physician. Having said that, it is generally true that if you are on TRT for an extended period of time (especially later in life) your pituitary gland stops producing LH/FSH and your testicles will no longer be able to produce testosterone in sufficient amount. My MO at Hopkins told me if I started TRT it was for life.
TRT in the setting of prostate cancer is, of course, controversial. I believe more urologists/MO/RO are beginning to believe that certain patients benefit from TRT if their T doesn't rebound after ADT is discontinued. I suspect that most experts would discontinue TRT if PSA is rising and maybe start again if PSA becomes undetectable for a period of time after therapy.
My personal, anecdotal experience is TRT was a game changer regarding my well being and amelioration of symptoms related to low T. QOL is very important to me.