@heavypilheavyphil the Mayo Clinic checks my PSA twice a year and I will be having a 3T mp MRI later this month. My two previous MRI's did not show any lesions, Pirads 2. My PSA is usually below 2. The whole thinking on testosterone has evolved alot in the last 5 years. Having a Gleason 6 like me stop TRT would be like have all men first diagnosed with Gleason 6 cancer immediately go on ADT. That just does not happen. I am 71 years old and play golf 3 times a week so I'm in fairly good shape. I've learned to just live with this cancer. When I was first diagnosed I certainly felt that I needed to do some treatment. But as you read the experiences of men on just about all of the treatments you find they mostly all have some negative issues. Its a tough deal. I study and research everything I can on prostate cancer knowing some day it may/will be time to treat it. The Mayo will probably do a biopsy again if something shows up on the MRI. From what I have read, prostate cancer is the only cancer where biopsy is done without an MRI in some instances. All other cancers they do an MRI first and only biopsy if something shows up. They never just start poking needles into the brain or some other area of cancer if there is nothing on the MRI.