I was out on TRT when my T didn't recover 2 years after triple therapy for G9 oligometastatic cancer. Mt PSA was undetectable and remained so for a year after TRT. Last week it was 0.2. There is no way to know if my PSA would have gone up without TRT or not. I know my QOL was hugely improved with TRT.

I believe current research is showing that TRT does not cause PSA to rise in selected patients and is beneficial.

Here is the abstract from a recent review article:

Review Article
Open access
Published: 26 November 2025
Testosterone replacement therapy following definitive treatment for prostate cancer: a scoping review of safety and efficacy

John Gibson, Michael George, Peter Grice, Amar Mohee, Theodora Stasinou, Ian Pearce & Vaibhav Modgil on Behalf of Manchester Andrology Research Collaborative (MARC)
International Journal of Impotence Research (2025)Cite this article

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Abstract
Testosterone replacement therapy (TRT) remains controversial in men with a history of prostate cancer due to historical concerns regarding oncologic safety. This scoping review aimed to systematically map existing evidence on the safety and efficacy of TRT in men following definitive treatment for prostate cancer. A systematic search of PubMed, CENTRAL, and Embase identified 447 records, from which 12 studies met inclusion criteria. Most were retrospective cohort studies, with sample sizes ranging from 10 to 152 men. TRT was not associated with an increased risk of biochemical recurrence or cancer progression in any included study. Reported PSA kinetics remained within expected post-treatment parameters, and several studies showed lower recurrence rates in TRT groups compared to controls. TRT consistently increased total and/or free testosterone and improved hypogonadal symptoms.