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← Return to Brinsupri experience after 3+ months
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Brinsupri experience after 3+ months
MAC & Bronchiectasis | Last Active: 3 days ago | Replies (21)Comment receiving replies
@whitemarsh Hi. sorry to hear about your skin problems. I've not started on the medication yet but have has numerous squamous skin cancers--some requiring surgery so interested in all the posts. Have you discussed this reaction with your doctor? Also, are you on the lower dosage? Perhaps you could take a break off the Brinsupri and see if your skin conditions show improvement. Good luck.
Replies to "@whitemarsh Hi. sorry to hear about your skin problems. I've not started on the medication yet..."
As an addition to discussion regarding skin changes on brinsupri:
Research found in the autosomal recessive immunodeficiency Papillon–Lefevre syndrome (PLS), the affected children almost invariably present with intractable suppurative gum infections (chronic gingivitis) that lead to loss of teeth by the age of 6–8 years (Pham et al., 2004; Pham, 2006). DPP1 is also expressed at high levels in the skin, and marked thickening of the skin of the palms and soles (hyperkeratosis) can result from failed keratinocyte desquamation at these sites.
a mutation in the DPP1 gene (CTSC), results in diffuse palmoplantar hyperkeratosis, severe prepubertal periodontitis, and premature loss of both deciduous and permanent teeth
Drugs like brinsupri depresses DPP 1 causing the skin and gum problems in people with PL.
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