@heavyphil the docs involved with my case are suspicious about my PET scan result, and my biopsy pathology - they've put in an order for one of their in house pathologists to redo the biopsy pathology, but it hasn't been done yet. So even though they have prescribed EBRT and 2 years of ADT emphatically, they have more uncertainty than usual, which I think accounts for this one mentioning they were talking up estrogen in their general talking shop discussions recently, and it might be an alternate in my case if he gets a completely different idea about what to do with me as or if new info comes in.

@heavyphil One thing I've found so far, from "Transdermal Estrogen May Offer Another Option for ADT in Men With Metastatic Prostate Cancer "

"Estradiol patches could be particularly attractive to patients who are on an LHRHa and troubled by side effects like hot flashes, Dr. James said. But they also have appeal from a cost standpoint, he added, whether for health systems or, in places like the United States, for patients who lack insurance or are underinsured.

“This sort of repurposing of an older, cheap drug,” Dr. James said, “is an important way to improve outcomes, separate from developing new drugs.”

I'm on Medicare Part D. The records I am sent indicate the US government pays the insurance company $40,000 per year minus a copay I'm insured for, for me to get Orgovyx. Estradiol would cost a tiny fraction of that. But if incoming data proves it should be the standard of care for many or even just some patients, many other jurisdictions will adopt and promote it.