I have been on Brinsupri for 3 months. My lungs feel clearer and less gunky and I have less and clearer mucus. I also have a pretty regular low grade headache and my blood pressure that had been managed on a very low dose BP med for 30 years elevated. My PCP has adjusted my BP med and added a diuretic but my ankles continue to swell so more adjustments are needed. Swollen ankles was never anything I ever had.