← Return to Smallest amount of prednisone for adrenal glands to work again?

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Profile picture for Mike @dadcue

This is not something for amateurs to manage on the internet.

I don't know the answer. It is hard to find any research on this topic. My endocrinologist instructed me to stay on 3 mg for an "extended period of time" until my cortisol level improved. My instructions were not precise and I was given leeway with my dose. I was also instructed to resist the temptation to increase or decrease my dose unless it was absolutely necessary if I wanted my cortisol level to improve. My endocrinologist offered to help me determine if my dose needed to be adjusted. The 3 mg dose is sometimes called a "maintenance dose" of prednisone for people diagnosed with adrenal insufficiency.

The following is some pertinent research that I have found. One is from 1970 and the other is more recent.
https://pubmed.ncbi.nlm.nih.gov/4321238/
and
https://pmc.ncbi.nlm.nih.gov/articles/PMC10388668/).
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I don't think there is a solution to the problem with prednisone induced adrenal insufficiency. I think we just hope for the best as we try to taper off prednisone. However, a "slow taper" isn't always the best option because staying on a low "fixed dose" is sometimes necessary.

We also need to prevent flares of PMR at the same time. Both of the problems with adrenal insufficiency and flares tend to happen concurrently at low doses of prednisone.

Good luck ... Prednisone might be the first miracle for treating our conditions. Getting off Prednisone is the second miracle that needs to happen.

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Replies to "This is not something for amateurs to manage on the internet. I don't know the answer...."

@dadcue , I don’t have PRM. I have secondary adrenal insufficiency from being on prednisone for asthma. Every time I have to stress dose it’s harder and harder to wean back down. I was finally down to 6 mg then had to stress dose for broken ribs and after being on 7 mg for 9 days (I was decreasing by 0.5 mg every 2 weeks), I passed out twice which earned me a 4 day stay in the hospital. There no one could figure out why I passed out. I was seemingly doing okay back up at 7.5 mg when the day of discharge I got a message from my long distance endocrinologist’s muse saying to go up to 9.5 mg. I did that and was supposed to decrease by 0.5 mg every few days which I didn’t tolerate at all so the Endo said okay decrease by 0.5 mg every week or 2. I haven’t been able to get below 9.5 mg since. When I dropped to 9 mg after being at 9.5 for 15 days, I started with all of the same symptoms again, headaches, dizziness, extreme fatigue, cold clammy sweats, feeling like I was going to collapse, so just tonight I increase back to 9.5 for the day by taking an additional 0.5 mg this evening when I couldn’t take feeling this bad any longer. I don’t know if this increase is even going to be enough to bring me out of this. Even after passing out twice my endo doesn’t think this had anything to do with adrenal insufficiency yet she increased my dose which seems strange to me. She says I look good on paper and I therefore shouldn’t really need more than 5 mg daily. At this point I don’t even know which way to turn. I feel like this stuff which I now call poison is going to kill me. I’m trying to get to Mayo to be be evaluated but have hit a road block with my insurance so I’m working on that. Prednisone has completely taken over my life and I couldn’t hate it more.