@stonewheel

Some people are able to discontinue their biologic after a period of time and they experience a sustained or permanent remission. In England, patients are required to stop Actemra after one year of treatment of GCA. Apparently it does not matter if they relapse. In England they go back on prednisolone (prednisone). In the United States, the biologic can be restarted if patients have relapses after stopping the biologic.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11079613/
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I have been on a biologic for 7 years. Attempts to discontinue it results in a gradual return of my symptoms along with a gradual increase in my inflammation markers. My relapses weren't like a sudden overnight increase in symptoms.
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Biologics don't actually "attack" anything that I know of. Prednisone might be said to attack muscles and bones but biologics don't do that. Artificial intelligence describes it this way:

"Biologics work by intercepting specific molecular signals or immune cells, preventing them from causing inflammation and tissue damage. This targeting is often described as "blocking" or "neutralizing" rather than a non-specific "attack". This specificity is why they typically have fewer side effects than traditional immunosuppressants like prednisone, which affects the entire body more broadly."