I recently brought up taking Azithromycin 3/week to my local ID doctor and she said I could try it but she was concerned about the resistance factor. So, it's interesting to hear that 250/mg 3/week does not cause resistance. I will bring up to my NJH ID doctor when I see her in the spring. I would be fine with taking a lower dose to help with the inflammation. I would think it would reduce mucous production as well.